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The Meters’ Leo Nocentelli To Lead Funk-Fueled Weekend At The Capitol Theatre

first_imgOn Friday, August 11th, and Saturday, August, 12th, Garcia’s at The Capitol Theatre is hosting a funk takeover led by the founding guitarist of The Meters, Leo Nocentelli. The two-day event dubbed “A Weekend of Funk & Friends” will feature Nocentelli both nights along with a number of special guests. For the Friday show, Jen Durkin — who got her nickname “Pipes” while touring with Connecticut’s Deep Banana Blackout — will bring her act, Steal Your Funk, to Port Chester, New York, performing funkified renditions of Grateful Dead classics along with funk standards. The next night, Jaguar will take to Garcia’s. Jaguar is an upbeat funk ensemble featuring Michelangelo Carubba and Craig Broadhead of Turkuaz, along with Beau Sasser of Kung Fu. You can purchase tickets to this funk-fueled weekend on The Capitol Theatre’s website here.last_img read more

Dialing down sickle cell disease

first_imgFlipping a single molecular switch can reverse illness in an animal model of sickle cell disease, according to a study by Harvard researchers at Children’s Hospital Boston (CHB) and Dana-Farber Cancer Institute (DFCI). When a protein called BCL11A is turned off, the body is able to manufacture red blood cells with an alternate form of hemoglobin unaffected by the mutation that causes the debilitating illness.The findings were reported online today in the journal Science by a research team led by Stuart H. Orkin, Harvard Medical School’s David G. Nathan Professor of Pediatrics at the Dana-Farber/Children’s Hospital Cancer Center (DF/CHCC). The results provide strong evidence that BCL11A could be a powerful treatment target for a significant global health problem that affects between 75,000 and 100,000 people in the United States. “This study provides the first proof of principle that BCL11A might serve as a target for treating sickle cell disease and related blood disorders such as the thalassemias,” said Stuart H. Orkin, Harvard Medical School’s David G. Nathan Professor of Pediatrics at the Dana-Farber/Children’s Hospital Cancer Center. File photo by Stephanie Mitchell/Harvard Staff Photographer“This study provides the first proof of principle that BCL11A might serve as a target for treating sickle cell disease and related blood disorders such as the thalassemias,” said Orkin, associate chief of the division of hematology/oncology at CHB and chair of pediatric oncology at Dana-Farber.First described more than 100 years ago, sickle cell disease (or sickle cell anemia) is an inherited blood ailment caused by a single mutation in one of the components of hemoglobin, the oxygen-carrying protein in red blood cells. The mutation reduces the protein’s ability to carry oxygen, and forces the cells to curve into a distinctive crescent or sickle shape, causing them to accumulate painfully and break apart in small blood vessels. The disease is found overwhelmingly in patients of African descent.The disease can only be cured with a bone marrow — blood stem cell — transplant, though difficulties in finding well-matched donors and the complications associated with transplantation rules this option out as an option for most patients. A drug called hydroxurea can provide some relief, but its mechanism of action is unclear and its effectiveness is unpredictable from patient to patient.Our bodies can manufacture two forms of hemoglobin: the adult form susceptible to the sickle cell mutation, and a fetal form that is largely produced during fetal development and for a short time after birth. Affected children first experience sickle cell symptoms around the time that their bodies switch from producing red blood cells with fetal hemoglobin to those with adult hemoglobin, at about 3 to 6 months old.BCL11A first drew serious attention in genome-wide association studies of sickle cell disease patients. Shortly after the genomic data came to light, Orkin, who is also a Howard Hughes Medical Institute investigator, and his colleagues showed that by genetically knocking out BCL11A they could activate fetal hemoglobin and silence mutated adult hemoglobin in cultured normal human red cell progenitors.“The red blood cell lineage performs a balancing act when it comes to manufacturing hemoglobin,” Orkin explained. “Increasing the production of one form reduces production of the other.”In the current study, Orkin’s team set out to assess the impact of removing BCL11A from the red blood cell lineage in adults. Using two different mouse models of human sickle cell disease as a means of cross-validation, they engineered a system whereby they could selectively turn the protein off just in the immature progenitor cells that give rise to red blood cells.The results in these mice were striking. Relieved of BCL11A’s influence, the mice in both models started producing red blood cells that showed no evidence of sickling, with no adverse impact on the level of cell production. Eighty-five percent of the red blood cells in the mice carried fetal hemoglobin, and on average 30 percent of the hemoglobin contained within these cells was of the fetal type. The mice also showed great improvement in a number of physiologic and clinical features.“We knew from previous clinical studies that the body needs to produce cells containing only 15 to 20 percent fetal hemoglobin to reverse disease,” Orkin said, “With these results, we know now we have a target that, if we can develop ways to inactivate or silence it clinically, could be very beneficial to people with sickle cell.”He and his colleague are already pursuing several lines of investigation aimed at broadening their understanding of BCL11A and translating their mouse findings into potential treatments.“We want to better understand the network of genes and proteins that interact with BCL11A, to see if any of them might also stand out as targets,” he said. “We also are screening the protein against libraries of chemicals in the hope of identifying compounds that interfere with it, and think it may also hold promise as a target for genetic therapies.”The study was supported by the National Heart, Lung and Blood Institute, the National Cancer Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Howard Hughes Medical Institute, and the Marie Betzner Morrow Endowment.last_img read more

Cable tie girdles

first_imgKeeping the sugar at the top”Girdling is normally done by using a knife to cut away a stripof the tree’s bark,” Taylor said. “The sugars that are producedby the tree can’t flow below the strip. But this damages the treeand increases the likelihood of insect and disease damage, too.”Taylor says some growers believe the traditional girdling methodshortens the life of the tree.For the past three years, Taylor has used cable ties to girdlepeach trees on test plots in middle Georgia, where 95 percent ofthe state’s peach crop grows.She straps the cable tie to the tree in the winter. In thespring, when the tree grows its peaches, the cable ties restrict theflow of sugars but don’t permanently damage the tree.”You remove the girdle after harvest, and the tree recovers,” shesaid. “And you can do it again the next winter.”Peach trees create sugars by photosynthesis and move them downinto the roots for storage. Girdling holds the sugars in theupper part of the tree, Taylor said, moving them up the tree andinto the fruit instead. Larger, sweeter peachesThe increase in sugar draws more water into the fruit. The resultis a sweeter, larger peach.”At the end of the fruiting season, we remove the girdle andallow the sugars to flow back to the roots,” she said.Girdling peach trees with cable ties results in earlier peaches,too, she said.”Earlier peaches translate into increased profits for thegrowers,” Taylor said. “They’ll be able to harvest three to fivedays earlier than they normally would. And the earlier you canget a crop to market, the greater the return.”Taylor said one large grower adopted the new girdling method lastseason and had a 5 percent increase in his highest-quality fruitcategory.”We’ve made a lot of progress for middle and late-season peachvarieties, but we don’t have the technique really optimized forour earlier-season varieties,” she said.Growers as far away as New Jersey and California have showninterest in the cable tie girdling method. “We had a grower inSouth Carolina try it on about 200 acres with very good results,”she said.Taylor believes the method can be applied easily to fruit cropslike apples and plums with similar results. It’s available now,but growers haven’t widely adopted it yet. By Sharon OmahenUniversity of GeorgiaA University of Georgia researcher is using cable ties to helppeach trees make sweeter, larger peaches.UGA stone-fruit horticulturist Kathy Taylor developed a methodthat uses cable ties, or strips of plastic like those used tobind computer cables, to control the sugar level in peach trees.The process, called girdling, isn’t new. But using cable tiesis.last_img read more

Holtsville IRS Building White Powder Scare Probed

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A white powder that was found at the IRS building in Holtsville set off a security scare on Tuesday afternoon, two weeks after tax day, local and federal authorities said.Suffolk County police Emergency Services Unit officers responded to the building on Waverly Avenue shortly after the suspicious substance was found 1 p.m., a police spokeswoman said.The powder was found in a plastic bag in the loading dock and was found to be non-toxic, according to a spokeswoman for the Internal Revenue Service.Investigators are analyzing the powder, police said.The incident came two weeks after a Mississippi allegedly mailed letters containing Ricin, a lethal biological warfare agent, to President Barack Obama, a U.S. senator and a Mississippi judge.last_img read more

Barclays gathers fire for £300m retail park fund

first_imgTo access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletterslast_img

COVID-19 pandemic a ‘wake-up call’ for multilateralism, Indonesia’s top diplomat says

first_imgA top diplomat from the Indonesian Foreign Ministry says the COVID-19 pandemic has served as a wake-up call for the multilateralism approach of diplomacy.The reason was that many countries had chosen to be reactive and protectionist at the early stage of the coronavirus outbreak, but later realized they needed to work together in a spirit of solidarity to battle the pandemic, said the ministry’s multilateral cooperation director general, Febrian Ruddyard.“It is a little bit contradictory, on one side [countries] tend to exclude themselves, but on the other side [they are aware that] collaborations are needed,” he said during a webinar on Thursday. “Thanks to the pandemic, we now know that our system is not ideal. It is crumbling amid the pandemic […] This will encourage us to look for a new format, which may not be a totally different one, but maybe something that can give dynamics [of the model of cooperation],” Febrian added.The coronavirus, which surfaced in China late last year, has killed nearly 420,000 people and infected some 7.4 million worldwide, according to worldometers.info.The pandemic has put half of humanity under some form of lockdown as countries scramble to counter the economic fallout from the coronavirus, which has also taken its toll on healthcare systems across the globe.Centre for Strategic and International Studies (CSIS) executive director Philips J. Vermonte agreed that the COVID-19 pandemic had highlighted vulnerabilities in various aspects of global and regional governance, particularly on the prevailing national interests linked to weaknesses that international institutions have.“Every country comes up with their own agendas to mitigate the impacts of the pandemic,” he said in the discussion on Thursday, calling on international communities to push cooperation and put nationalism and protectionism at bay.In this context, Febrian suggested an optimistic idea to shift the basis of multilateral cooperation, which traditionally was made and determined through historical factors, to move forward and become more practical and future-oriented.“In the past, many [international] organizations were established after a problem, not to mitigate potential problems. This kind of way of thinking must change,” he said.Topics : “We can call it a wake-up call for multilateralism, where the old system [of multilateralism] that had been built is forced to remain effective [amid the pandemic] to fulfill the needs of the people, while at the same time, the global panic has caused many countries to push forward domestic interests,” Febrian explained, citing the protectionist mindset in global trade as an example.Indonesia would remain consistent in promoting multilateralism to find equitable solutions, particularly for mitigating the global pandemic, he added.Moreover, Febrian said he believed the pandemic could give added value to multilateral cooperation as it provided room for countries to conduct a “reality check” on the readiness of their approach in response to the health crisis.“It also provided [countries] with an opportunity to revitalize multilateral cooperation, for instance, in the realm of global health management,” he said, adding that the reality check would allow the international community to evaluate whether the current system was ideal.last_img read more

House to question attorney general on ‘light’ sentence sought for suspects in Novel case

first_img“We will ask the attorney general in a hearing at the end of this month. It will be one of the agenda points,” the ruling Indonesian Democratic Party of Struggle (PDI-P) politician said.Herman, however, refused to comment on the sentence demand, noting that the judges handling the case had yet to hand down the verdict.”We don’t have access to the police investigation report. We cannot interfere with the case. The investigator is also not allowed to give the material to us,” he said, “But since this [case] has sparked controversy, we will ask the attorney general later.”The one-year prison sentences sought for the defendants, Chief Brig. Ronny Bugis and Brig. Rahmat Kadir, has left many people disappointed. Some expressed their bewilderment over the short imprisonment demanded by the prosecutors through sarcastic videos and memes in social media. Read also: 1-year prison sentence demanded for cops who allegedly attacked Novel BaswedanRonny and Rahmat have been accused of attacking Novel with acid because of the latter’s work as an investigator for the KPK, which saw several powerful and corrupt politicians and government officials, as well as police officers, end up behind bars. Shortly after he was arrested, Ronny said he considered Novel, who previously served as a police officer, a traitor.Noting that the attack had left the KPK investigator disabled for the rest of his life, Commission III lawmaker Habiburokhman said the prison sentence demanded for the alleged attackers was “too light”.“The one-year sentence hurts our sense of justice,” the Gerindra Party politician said.He contrasted the sentence demand with at least three acid attack cases that had been brought to trial before, in which prosecutors demanded 10-year prison sentences each for defendants in the Bengkulu District Court in Bengkulu and the Pekalongan District Court in Central Java. Prosecutors demanded 3.5 years of imprisonment for the defendant in a similar case at the Denpasar District Court in Bali.”I will not interfere in the case, but logically, the sentences for Novel’s [attackers] should be heavier than the three aforementioned cases,” he said.Topics : House of Representatives Commission III, which oversees legal affairs, is set to question Attorney General ST Burhanuddin regarding the one-year prison sentence demanded by prosecutors for two police officers accused of attacking Corruption Eradication Commission (KPK) investigator Novel Baswedan.Commission III chairman Herman Hery said on Monday that lawmakers would invite ST Burhanuddin for a hearing and demand an explanation.last_img read more

South Africa 59% excess deaths imply hidden COVID-19 toll

first_imgSouth Africa witnessed some 17,000 extra deaths from natural causes or 59% more than would normally be expected between early May and mid-July, scientists said, suggesting many more people are dying of COVID-19 than shown in official figures.New data by the South African Medical Research Council (SAMRC), released overnight, showed that just in the week to July 14 – the latest figures available – there was an excess of 5,022 deaths by natural causes, about half more than usual.Africa’s most industrialized nation is in the middle of a runaway epidemic of the coronavirus, with cases increasing by more than 10,000 day and the current total approaching 400,000. Lockdown eased before peakPresident Cyril Ramaphosa implemented a tough lockdown at the end of March, shutting shops, ordering people to stay home and sending the army on to the streets to enforce it, back when South Africa had only 400 recorded cases.But a surge in poverty and unemployment in a country that already had too much of both spurred the government to lift restrictions well before the peak of infections.The council’s data showed 17,090 extra deaths, 11,175 were people over the age of 60, a telltale sign of COVID-19, which is overwhelmingly more deadly for older people.Addressing parliament by teleconference on Thursday, Health Minister Zweli Mkhize acknowledged the SAMRC figures, adding that they were “comparable to countries like India and Russia, but significantly lower than the UK or Spain.”Ramaphosa said this month that scientists had predicted up to 50,000 coronavirus deaths in South Africa, a figure which seems possible based on Thursday’s findings by the council. Topics : But its recorded death toll is low, at 5,940 deaths or less than 1.5 percent of cases.Debbie Bradshaw, chief specialist scientist at the government-funded research council, said the figures revealed “a huge discrepancy” between the confirmed COVID-19 death toll and the excess natural deaths.Richard Lessells, an infectious disease specialist at the KwaZulu-Natal Research Innovation and Sequencing Platform in eastern South Africa, said the figures were not surprising because the same pattern could be seen in other countries.It could partly reflect other knock-on effects in the health system, such as “if I have a stroke at home and my family decide they don’t want to take me to hospital because it’s too risky and I die at home.”last_img read more

Kostas Manolas unsure over Roma future amid Arsenal transfer speculation

first_img Comment Unai Emery is keen to upgrade his defensive options next season (Picture: Getty)Arsenal are unlikely to have a free run at Manolas, though, with Manchester United also looking to bring him to the Premier League while Juventus and Napoli could offer the defender the opportunity to remain in Italy.Unai Emery has prioritised the signing of a central defender this summer in a bid to address the club’s shortcomings in that area of the pitch. Among the names linked to Arsenal are Barcelona’s World Cup winner Samuel Umtiti, Espanyol’s Mario Hermoso and Saint-Etienne teenager William Saliba.Arsenal conceded considerably more goals than the top-four Premier League clubs and also let in more than mid-table sides Wolves, Everton and Leicester City as well as bottom half Newcastle United this season.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityHow much money Emery has to spend in the transfer market will largely depend on whether or not Arsenal can beat Chelsea in the Europa League final and in doing so qualify for next season’s Champions League.Manolas made 35 appearances for Roma in all competitions this season scoring twice and he would link up with his international defensive partner Sokratis Papastathopolous if he moves to the Emirates.More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal Metro Sport ReporterTuesday 28 May 2019 1:46 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link201Shares Advertisement Kostas Manolas unsure over Roma future amid Arsenal transfer speculation Kostas Manolas could leave Roma this summer (Picture: Getty)Reported Arsenal target Kostas Manolas has hinted that his five-year spell with Roma could come to an end this summer.The 27-year-old Greece international moved to Roma from Olympiacos in 2014 and has since established himself as one of the most consistent defenders in Serie A.However, he is one of a number of players tipped to depart the Italian capital following Roma’s failure to secure Champions League football with the highly-rated teenager Nicolo Zaniolo and Turkish winger Cengiz Under, among those linked with moves elsewhere.Manolas has been frequently touted with a potential move to the Premier League in recent years and it has been reported in Italy that Arsenal are prepared to match a £32m release clause in his contract to bring him to north London.AdvertisementAdvertisementADVERTISEMENTAddressing his future after Roma’s 2-1 win over Parma on the final day of the season on Saturday, Manolas told reporters: ‘I don’t know if I’ll stay here.’ Advertisementlast_img read more

Report: Colorado marijuana use No.1 in nation among teens, adults

first_imgThe Denver Channel 11 October 2017Family First Comment: Still want to liberalise drug laws? Of course not!“Colorado youth now ranks No. 1 in the nation for marijuana use and 55 percent higher than the national average. Adult use in the state also comes up on top, which the report notes is 124 percent higher than the national average.”www.saynopetodope.nzMarijuana usage among Coloradans, both young and old, has increased significantly since the drug was legalized and now the state ranks No. 1 in consumption in both age groups, according to a new report released Tuesday.The report, prepared by investigators with the Rocky Mountain High Intensity Drug Trafficking Area (RMHIDTA), details some of the negative impacts marijuana legalization has had on Colorado.According to the 168-page report, Colorado youth now ranks No. 1 in the nation for marijuana use and 55 percent higher than the national average. Adult use in the state also comes up on top, which the report notes is 124 percent higher than the national average.The spike in usage could be contributing to an increase in marijuana-related traffic deaths, the report found. Since 2013, RMHIDTA says marijuana-related traffic deaths more than doubled to approximately one death every three days.In 2016, 20 percent of all traffic deaths were marijuana-related compared to only 9 percent six years ago, the report found.The report also points out that seizures of Colorado marijuana to other states increased 20 percent by vehicle and over 300 percent by parcels.The authors of the report say the findings are based on available data and information from a variety of credible sources.http://www.thedenverchannel.com/news/local-news/marijuana/report-colorado-marijuana-use-no1-in-nation-among-teens-adultslast_img read more